Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model

Chenghung Yeh; Song Hu; Jinyang Liang; Lei Li; Brian Soetikno; Zhi Hong Lu; Rebecca E. Sohn; Konstantin Maslov; Jeffrey M. Arbeit; Lihong V. Wang

doi:10.1117/12.2082948

11 March 2015 Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model

Chenghung Yeh, Song Hu, Jinyang Liang, Lei Li, Brian Soetikno, Zhi Hong Lu, Rebecca E. Sohn, Konstantin Maslov, Jeffrey M. Arbeit, Lihong V. Wang

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93233H (2015) https://doi.org/10.1117/12.2082948
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO₂), and thereby the metabolic rate of oxygen (MRO₂), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO2 difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO₂.

Citation Download Citation

Chenghung Yeh, Song Hu, Jinyang Liang, Lei Li, Brian Soetikno, Zhi Hong Lu, Rebecca E. Sohn, Konstantin Maslov, Jeffrey M. Arbeit, and Lihong V. Wang "Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233H (11 March 2015); https://doi.org/10.1117/12.2082948

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