Photodynamic therapy as a new approach in vulvovaginal candidiasis in murine model

Maria E. Santi M.D.; Rubia G. Lopes; Renato A. Prates; Aline Sousa; Luis R. Ferreira; Adjaci U. Fernandes; Sandra K. Bussadori; Alessandro M. Deana

doi:10.1117/12.2078014

26 February 2015 Photodynamic therapy as a new approach in vulvovaginal candidiasis in murine model

Maria E. Santi M.D., Rubia G. Lopes, Renato A. Prates, Aline Sousa, Luis R. Ferreira, Adjaci U. Fernandes, Sandra K. Bussadori, Alessandro M. Deana

Author Affiliations +

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93032H (2015) https://doi.org/10.1117/12.2078014
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Vulvovaginal candidiasis is a common cause of vaginal infections. This study investigates the efficiency of antimicrobial photodynamic therapy (aPDT) against yeast cells in mice. Methylene blue (MB), malachite green (MG), and a special designed protoporphirin (PpNetNI) were used as photosensitizers. Female BALB-c mice were infected with Candida albicans ATCC 90028. PDT was applied with two different light sources, intravaginal and transabdominal. Vaginal washes were performed and cultivated for microbial quantification. Antimicrobial PDT was able to decrease microbial content with MB and PpNetNI (p<0.05), it was not effective, however, with MG photosensitizer. The results of this study demonstrate that aPDT may be a viable alternative treatment for vaginal candidiasis.

Citation Download Citation

Maria E. Santi M.D., Rubia G. Lopes, Renato A. Prates, Aline Sousa, Luis R. Ferreira, Adjaci U. Fernandes, Sandra K. Bussadori, and Alessandro M. Deana "Photodynamic therapy as a new approach in vulvovaginal candidiasis in murine model", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032H (26 February 2015); https://doi.org/10.1117/12.2078014

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available