Nanoscale imaging of neurotoxic proteins

Clemens F. Kaminski; Dorothea Pinotsi; Claire H. Michel; Gabriele S Kaminski Schierle

doi:10.1117/12.2062721

28 August 2014 Nanoscale imaging of neurotoxic proteins

Clemens F. Kaminski, Dorothea Pinotsi, Claire H. Michel, Gabriele S Kaminski Schierle

Proceedings Volume 9169, Nanoimaging and Nanospectroscopy II; 91690N (2014) https://doi.org/10.1117/12.2062721
Event: SPIE NanoScience + Engineering, 2014, San Diego, California, United States

Abstract

The misfolding and self-assembly of intrinsically disordered proteins into insoluble amyloid structures is central to many neurodegenerative diseases such as Alzheimer’s and Parkinson’s Diseases. Optical imaging of this self-assembly process in vitro and in cells is revolutionising our understanding of the molecular mechanisms behind these devastating diseases. In contrast to conventional biophysical methods, optical imaging, and in particular optical super-resolution imaging, permit the dynamic investigation of the molecular self-assembly process in vitro and in cells, at molecular level resolution. In this article, current state-of-the-art imaging methods are reviewed and discussed in the context of research into neurodegeneration.

Citation Download Citation

Clemens F. Kaminski, Dorothea Pinotsi, Claire H. Michel, and Gabriele S Kaminski Schierle "Nanoscale imaging of neurotoxic proteins", Proc. SPIE 9169, Nanoimaging and Nanospectroscopy II, 91690N (28 August 2014); https://doi.org/10.1117/12.2062721

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available