Construct a new method accurately extracting parameters associate with absorption and scattering coefficients of epithelium and stroma: using perpendicular and oblique fiber bundle probes

H. P. Hsieh; K. B. Sung; F. W. Hsu

doi:10.1117/12.2051924

8 May 2014 Construct a new method accurately extracting parameters associate with absorption and scattering coefficients of epithelium and stroma: using perpendicular and oblique fiber bundle probes

H. P. Hsieh, K. B. Sung, F. W. Hsu

Author Affiliations +

Proceedings Volume 9129, Biophotonics: Photonic Solutions for Better Health Care IV; 91291S (2014) https://doi.org/10.1117/12.2051924
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

Diffuse reflectance spectroscopy has been applied as a non-invasive method to measure tissue optical properties, which are associate with anatomical information. The algorithm widely used to extract, optical parameters from reflectance spectra is the regression method, which is time-consuming and frequently converge to local maxima. In this study, the effects of parameters changes on spectra are analyzed in different fiber geometries, source-detector separations and wavelengths. In the end of this paper, a new fitting algorithm is proposed base on parameters features found. The new algorithm is expected to enhance the accuracy of parameters extracted and save 75% of the process time.

Citation Download Citation

H. P. Hsieh, K. B. Sung, and F. W. Hsu "Construct a new method accurately extracting parameters associate with absorption and scattering coefficients of epithelium and stroma: using perpendicular and oblique fiber bundle probes", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91291S (8 May 2014); https://doi.org/10.1117/12.2051924

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