Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

A. N. Pavlov; O. V. Semyachkina-Glushkovskaya; V. V. Lychagov; O. A. Bibikova; S. S. Sindeev; O. N. Pavlova; E. P. Shuvalova; V. V. Tuchin

doi:10.1117/12.2051896

8 May 2014 Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

A. N. Pavlov, O. V. Semyachkina-Glushkovskaya, V. V. Lychagov, O. A. Bibikova, S. S. Sindeev, O. N. Pavlova, E. P. Shuvalova, V. V. Tuchin

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Proceedings Volume 9129, Biophotonics: Photonic Solutions for Better Health Care IV; 91290P (2014) https://doi.org/10.1117/12.2051896
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

Using Doppler optical coherence tomography (DOCT) we study stress-related intracranial hemorrhages (ICHs) in newborn rats. We investigate a masked stage of ICH development that corresponds to the first 4 h after the stress. We show that this period is characterized by significant changes in the diameter of the sagittal vein and the velocity of the cerebral venous blood flow (CVBF). We discuss diagnostic abilities of wavelet-based methods and consider an adaptive technique allowing us to reveal clearest distinctions in the dynamics of CVBF between normal and stressed newborn rats. Finally, we conclude that the venous insufficiency in newborns and a reduced response of the sagittal vein to adrenaline are related to important prognostic markers of the risk of ICH development.

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A. N. Pavlov, O. V. Semyachkina-Glushkovskaya, V. V. Lychagov, O. A. Bibikova, S. S. Sindeev, O. N. Pavlova, E. P. Shuvalova, and V. V. Tuchin "Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91290P (8 May 2014); https://doi.org/10.1117/12.2051896

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KEYWORDS

Veins

Diagnostics

Blood circulation

Optical coherence tomography

Optical imaging

Wavelets

Brain

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