ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Irina Martynenko; Vera Kuznetsova; Anna Orlova; Pavel Kanaev; Yulia Gromova; Vladimir Maslov; Alex Baranov; Anatoly Fedorov

doi:10.1117/12.2052528

2 May 2014 ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Irina Martynenko, Vera Kuznetsova, Anna Orlova, Pavel Kanaev, Yulia Gromova, Vladimir Maslov, Alex Baranov, Anatoly Fedorov

Author Affiliations +

Proceedings Volume 9126, Nanophotonics V; 91263C (2014) https://doi.org/10.1117/12.2052528
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

In present study complexes between non-toxic ZnSe/ZnS quantum dots and chlorin e6 molecules that are widely used as photosensitizers in photodynamic therapy were formed. It was found that in aqueous solution cationic ZnSe/ZnS quantum dots and chlorin e6 formed stable complexes that exhibit efficient photoexcitation energy transfer from quantum dots to molecules. Spectroscopic methods were applied to evaluate the energy transfer efficiency. Stoichiometry of these complexes was studied. Additionally, the photodynamic therapy efficacy of the quantum dotchlorin e6 complexes was in vitro assessed against Ehrlich ascites carcinoma cancer cell line using a trypan blue assay. We found that complex offered an improved cancer cell photodynamic destruction effect as compared to that of free chlorin e6.

Citation Download Citation

Irina Martynenko, Vera Kuznetsova, Anna Orlova, Pavel Kanaev, Yulia Gromova, Vladimir Maslov, Alex Baranov, and Anatoly Fedorov "ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect", Proc. SPIE 9126, Nanophotonics V, 91263C (2 May 2014); https://doi.org/10.1117/12.2052528

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available