Relationship of ultrasound signal intensity with SonoVue concentration at body temperature in vitro

Xin Yang; Jing Li; Xiaoling He; Kaizhi Wu; Yun Yuan; Mingyue Ding

doi:10.1117/12.2044395

9 April 2014 Relationship of ultrasound signal intensity with SonoVue concentration at body temperature in vitro

Xin Yang, Jing Li, Xiaoling He, Kaizhi Wu, Yun Yuan, Mingyue Ding

Proceedings Volume 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging; 903824 (2014) https://doi.org/10.1117/12.2044395
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

In this paper, the relationship between image intensity and ultrasound contrast agent (UCA) concentration is investigated. Experiments are conducted in water bath using a silicon tube filled with UCA (SonoVue) at different concentrations (100μl/l to 6000μl/l) at around 37 °C to simulate the temperature in human body. The mean gray-scale intensity within the region of interest (ROI) is calculated to obtain the plot of signal intensity to UCA concentration. The results show that the intensity firstly exhibits a linear increase to the peak at approximately 1500μl/l then appears a downward trend due to the multiple scattering (MS) effects.

Citation Download Citation

Xin Yang, Jing Li, Xiaoling He, Kaizhi Wu, Yun Yuan, and Mingyue Ding "Relationship of ultrasound signal intensity with SonoVue concentration at body temperature in vitro", Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 903824 (9 April 2014); https://doi.org/10.1117/12.2044395

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