Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion

John M. Irvine; John Regan; Tammy A. Spain; Joseph D. Caruso; Maricela Rodriquez; Rajiv Luthra; Jonathon Forsberg; Nicole J. Crane; Eric Elster

doi:10.1117/12.2043958

11 March 2014 Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion

John M. Irvine, John Regan, Tammy A. Spain, Joseph D. Caruso, Maricela Rodriquez, Rajiv Luthra, Jonathon Forsberg, Nicole J. Crane, Eric Elster

Author Affiliations +

Proceedings Volume 9037, Medical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment; 90371F (2014) https://doi.org/10.1117/12.2043958
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Ischemia and reperfusion injuries present major challenges for both military and civilian medicine. Improved methods for assessing the effects and predicting outcome could guide treatment decisions. Specific issues related to ischemia and reperfusion injury can include complications arising from tourniquet use, such as microvascular leakage in the limb, loss of muscle strength and systemic failures leading to hypotension and cardiac failure. Better methods for assessing the viability of limbs/tissues during ischemia and reducing complications arising from reperfusion are critical to improving clinical outcomes for at-risk patients. The purpose of this research is to develop and assess possible prediction models of outcome for acute limb ischemia using a pre-clinical model. Our model relies only on non-invasive imaging data acquired from an animal study. Outcome is measured by pathology and functional scores. We explore color, texture, and temporal features derived from both color and thermal motion imagery acquired during ischemia and reperfusion. The imagery features form the explanatory variables in a model for predicting outcome. Comparing model performance to outcome prediction based on direct observation of blood chemistry, blood gas, urinalysis, and physiological measurements provides a reference standard. Initial results show excellent performance for the imagery-base model, compared to predictions based direct measurements. This paper will present the models and supporting analysis, followed by recommendations for future investigations.

Citation Download Citation

John M. Irvine, John Regan, Tammy A. Spain, Joseph D. Caruso, Maricela Rodriquez, Rajiv Luthra, Jonathon Forsberg, Nicole J. Crane, and Eric Elster "Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion", Proc. SPIE 9037, Medical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment, 90371F (11 March 2014); https://doi.org/10.1117/12.2043958

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available