High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography

Hrebesh M. Subhash; Sean O'Gorman; Kai Neuhaus; Martin Leahy

doi:10.1117/12.2038550

12 March 2014 High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography

Hrebesh M. Subhash, Sean O'Gorman, Kai Neuhaus, Martin Leahy

Author Affiliations +

Proceedings Volume 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics; 895106 (2014) https://doi.org/10.1117/12.2038550
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

In this paper we demonstrate a novel application of correlation mapping optical coherence tomography (cm-OCT) for volumetric nailfold capillaroscopy (NFC). NFC is a widely used non-invasive diagnostic method to analyze capillary morphology and microvascular abnormalities of nailfold area for a range of disease conditions. However, the conventional NFC is incapable of providing volumetric imaging, when volumetric quantitative microangiopathic parameters such as plexus morphology, capillary density, and morphologic anomalies of the end row loops most critical. cm-OCT is a recently developed well established coherence domain magnitude based angiographic modality, which takes advantage of the time-varying speckle effect, which is normally dominant in the vicinity of vascular regions compared to static tissue region. It utilizes the correlation coefficient as a direct measurement of decorrelation between two adjacent B-frames to enhance the visibility of depth-resolved microcirculation.

Citation Download Citation

Hrebesh M. Subhash, Sean O'Gorman, Kai Neuhaus, and Martin Leahy "High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 895106 (12 March 2014); https://doi.org/10.1117/12.2038550

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available