Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo; Paul J. Derry; Boris Ermolinsky; Richard Su; André Conjusteau; Sergey Ermilov; Eugene R. Zubarev; Alexander Oraevsky

doi:10.1117/12.2044628

3 March 2014 Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo, Paul J. Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene R. Zubarev, Alexander Oraevsky

Author Affiliations +

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 894368 (2014) https://doi.org/10.1117/12.2044628
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Gold-based contrast agents, gold nanorod (GNR), were designed for the enhancement of optoacoustic signal. After synthesis, the GNR-CTAB complexes were modified by pegylation (PEG), or replacement of CTAB (cetyl trimethylammonium bromide) with MTAB (16-mercaptohexadecyl trimethylammonium bromide) for coverage of gold nanorods with heparin (GNR-HP). Modified GNR are purified through centrifugation and filtration. GNRCTAB can be used as a model of positively charged gold surface for quantitative optoacoustic sensing in GNRbacteria interactions, whereas GNR-PEG and GNR-HP can be used as negatively charged gold surface models. We studied controlled agglomeration of contrast agents with the bacteria E.Coli and Vibrio Cholerae. For bacterial sensing, the localized plasmon resonance peak shifts as a function of electrostatic binding, which was detected with two different wavelengths through 3D optoacoustic imaging.

Citation Download Citation

Anton Liopo, Paul J. Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene R. Zubarev, and Alexander Oraevsky "Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894368 (3 March 2014); https://doi.org/10.1117/12.2044628

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available