Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results

Pablo A. Valdés; Valerie L. Jacobs; Frederic Leblond; Brian C. Wilson; Keith D. Paulsen; David W. Roberts

doi:10.1117/12.2039090

20 March 2014 Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results

Pablo A. Valdés, Valerie L. Jacobs, Frederic Leblond, Brian C. Wilson, Keith D. Paulsen, David W. Roberts

Author Affiliations +

Proceedings Volume 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 892809 (2014) https://doi.org/10.1117/12.2039090
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrallyresolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpIX, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared.

Citation Download Citation

Pablo A. Valdés, Valerie L. Jacobs, Frederic Leblond, Brian C. Wilson, Keith D. Paulsen, and David W. Roberts "Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results", Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892809 (20 March 2014); https://doi.org/10.1117/12.2039090

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