Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde; Jennifer-M. Masch; Dirk Theisen-Kunde; Martin Marczynski-Bühlow; Georg Lutter; Ralf Brinkmann

doi:10.1117/12.2033550

24 June 2013 Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, Ralf Brinkmann

Proceedings Volume 8803, Medical Laser Applications and Laser-Tissue Interactions VI; 88030I (2013) https://doi.org/10.1117/12.2033550
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

Aiming for laser-assisted resection of calcified aortic valve structures for Transcatheter Aortic Valve Implantation (TAVI), a Q-switched Tm:YAG laser emitting at a wavelength of 2.01 μm was used to evaluate the cutting efficiency on highly calcified human aortic leaflets in-vitro. The calcified aortic leaflets were examined regarding ablation rates and debris generation, using a pulse energy of 4.3 mJ, a pulse duration of 0.8-1 μs and a repetition rate of 1 kHz. The radiation was transmitted via a 200 μm core diameter quartz fiber. Resection was performed in a fiber-tissue contact mode on water-covered samples in a dish. The remnant particles were analyzed with respect to quantity and size by light microscopy. Additionally, soft tissue of porcine aortic vessels was examined for histologically detectable thermo-mechanical damage after continuous wave and Q-switched 2μm laser irradiation. An ablation rate of 36.7 ± 25.3 mg/min could be realised on highly calcified aortic leaflets, with 85.4% of the remnant particles being <6 μm in diameter. The maximum damaged area of the soft tissue was < 1 mm for both, cw and pulsed laser irradiation. This limits the expected collateral damage of healthy tissue during the medical procedure. Overall, the Q-switched Tm:YAG laser system showed promising results in cutting calcified aortic valves, transmitting sufficient energy through a small flexible fibre.

Citation Download Citation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, and Ralf Brinkmann "Cardiovascular damage after cw and Q-switched 2μm laser irradiation", Proc. SPIE 8803, Medical Laser Applications and Laser-Tissue Interactions VI, 88030I (24 June 2013); https://doi.org/10.1117/12.2033550

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available