Hybrid nanocomposite coatings from metal (Mg alloy)-drug  deposited onto medical implant by laser adaptive ablation deposition technique

Valery Serbezov; Sotir Sotirov; Svetlin Serbezov

doi:10.1117/12.2012006

15 March 2013 Hybrid nanocomposite coatings from metal (Mg alloy)-drug deposited onto medical implant by laser adaptive ablation deposition technique

Valery Serbezov, Sotir Sotirov, Svetlin Serbezov

Author Affiliations +

Proceedings Volume 8770, 17th International School on Quantum Electronics: Laser Physics and Applications; 87700G (2013) https://doi.org/10.1117/12.2012006
Event: Seventeenth International School on Quantum Electronics: Laser Physics and Applications, 2012, Nessebar, Bulgaria

Abstract

Drug-eluting medical implants are active implants whose function is to create healing effects. The current requirements for active medical coatings for Drug-eluting medical implants are to be biocompatible, biodegradable, polymer free, mechanically stable and enable a controlled release of one or more drugs and defined degradation. This brings hybrid nanocomposite coatings into focus especially in the field of cardiovascular implants. We studied the properties of Metal (Mg alloy)-Paclitaxel coatings obtained by novel Laser Adaptive Ablation Deposition Technique (LAAD) onto cardiovascular stents from 316 LVM stainless steel material. The morphology and topology of coatings were studied by Bright field / Fluorescence optical microscope and Scanning Electron Microscope (SEM). Comparative measurements were made of the morphology and topology of hybrid, polymer free nanocomposite coatings deposited by LAAD and polymerdrug coatings deposited by classical spray technique. The coatings obtained by LAAD are homogeneous without damages and cracks. Metal nanoparticles with sizes from 40 nm to 230 nm were obtained in drug matrixes. Energy Dispersive X-ray Spectroscopy (EDX) was used for identification of metal nanoparticles presence in hybrid nanocomposites coatings. The new technology opens up possibilities to obtain new hybrid nanocomposite coatings with applications in medicine, pharmacy and biochemistry.

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Valery Serbezov, Sotir Sotirov, and Svetlin Serbezov "Hybrid nanocomposite coatings from metal (Mg alloy)-drug deposited onto medical implant by laser adaptive ablation deposition technique", Proc. SPIE 8770, 17th International School on Quantum Electronics: Laser Physics and Applications, 87700G (15 March 2013); https://doi.org/10.1117/12.2012006

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KEYWORDS

Magnesium

Nanocomposites

Polymers

Optical coatings

Nanoparticles

Metals

Scanning electron microscopy

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