MRI-based hemodynamical analysis in patients with surgically treated aortic coarctations

Michael Delles; Manuela Noe; Yoo-Jin Jeong; Sebastian Ley; Hendrik von Tengg-Kobligk; Hans-Ulrich Kauczor; Rüdiger Dillmann; Roland Unterhinninghofen

doi:10.1117/12.2006734

29 March 2013 MRI-based hemodynamical analysis in patients with surgically treated aortic coarctations

Michael Delles, Manuela Noe, Yoo-Jin Jeong, Sebastian Ley, Hendrik von Tengg-Kobligk, Hans-Ulrich Kauczor, Rüdiger Dillmann, Roland Unterhinninghofen

Author Affiliations +

Proceedings Volume 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging; 867209 (2013) https://doi.org/10.1117/12.2006734
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

In management of cardiovascular diseases, information about the patient-specific behavior of blood flow and pressure can be essential. In the human aorta, velocity-encoded magnetic resonance imaging (MRI) is the only method capable of measuring complete time-resolved three-dimensional vector fields of the blood flow velocities. Additionally, computations of relative blood pressure from this data source have been presented in recent years. Thus, velocityencoded MRI can be a valuable measurement technique for both blood flow and blood pressure values in diagnostics and therapy control of aortic diseases. In the last years, we have developed the software framework MEDIFRAME for cardiovascular diagnostics based on MRI acquisitions. In this article, we apply our in-house developed software framework for a MRI-based hemodynamic analysis in five patients with surgically treated aortic coarctations. We compared our results to a control group of five healthy volunteers. The study included the measurement of blood flow velocities by phase-contrast MRI and the subsequent computation of relative blood pressure values. We generated a set of suitable visualizations for flow and pressure and created centerline diagrams of the cross-sectional area, flow and mean relative blood pressure. Additionally, characteristic values were computed from the centerline diagrams for every subject. In the vast majority of the visualization and quantification techniques of our software framework, we observed significant effects of the treated aortic coarctations. Therefore, we draw the conclusion that this kind of MRI-based hemodynamic analysis can be a valuable tool for diagnostics and therapy control of aortic coarctations.

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Michael Delles, Manuela Noe, Yoo-Jin Jeong, Sebastian Ley, Hendrik von Tengg-Kobligk, Hans-Ulrich Kauczor, Rüdiger Dillmann, and Roland Unterhinninghofen "MRI-based hemodynamical analysis in patients with surgically treated aortic coarctations", Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 867209 (29 March 2013); https://doi.org/10.1117/12.2006734

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KEYWORDS

Blood pressure

Blood circulation

Magnetic resonance imaging

Visualization

Software frameworks

Diagnostics

Hemodynamics

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