Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography

Jun Xia; Muhammad Chatni; Konstantin Maslov; Lihong V. Wang

doi:10.1117/12.2004937

4 March 2013 Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography

Jun Xia, Muhammad Chatni, Konstantin Maslov, Lihong V. Wang

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85810K (2013) https://doi.org/10.1117/12.2004937
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Due to the wide use of animals for human disease studies, small animal whole-body imaging plays an increasingly important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose metabolic information, leading to higher costs of building dual-modality systems. Even with image coregistration, the spatial resolution of the metabolic imaging modality is not improved. We present a ring-shaped confocal photoacoustic computed tomography (RC-PACT) system that can provide both assessments in a single modality. Utilizing the novel design of confocal full-ring light delivery and ultrasound transducer array detection, RC-PACT provides full-view cross-sectional imaging with high spatial resolution. Scanning along the orthogonal direction provides three-dimensional imaging. While the mouse anatomy was imaged with endogenous hemoglobin contrast, the glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. Through mouse tumor models, we demonstrate that RC-PACT may be a paradigm shifting imaging method for preclinical research.

Citation Download Citation

Jun Xia, Muhammad Chatni, Konstantin Maslov, and Lihong V. Wang "Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810K (4 March 2013); https://doi.org/10.1117/12.2004937

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