Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate

Laura A. Sordillo; B. B. Das; Yang Pu; Kexian Liang; Giovanni Milione; Peter P. Sordillo; Sam Achilefu; R. R. Alfano

doi:10.1117/12.2003102

19 March 2013 Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate

Laura A. Sordillo, B. B. Das, Yang Pu, Kexian Liang, Giovanni Milione, Peter P. Sordillo, Sam Achilefu, R. R. Alfano

Author Affiliations +

Proceedings Volume 8577, Optical Biopsy XI; 857708 (2013) https://doi.org/10.1117/12.2003102
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Time-resolved fluorescence was used to investigate malignant and normal adjacent breast tissues stained with a conjugate of indocyanine green and octreotate. A marked increase in fluorescence lifetime intensity was seen in the breast cancer sample compared to the normal sample. The fluorescent lifetimes were also investigated and showed similar fluorescence decay curves in stained malignant and normal breast tissue. These results confirm that somatostatin receptors occur on human breast carcinomas, suggest that the presence of somatostatin receptors should be investigated as a marker of breast cancer aggressiveness, and suggest that this conjugate might be used to detect the presence of residual breast cancer after surgery, allowing better assessment of tumor margins and reducing the need for second or repeat biopsies in selected patients. These results may also provide clues for designing future treatment options for breast cancer patients.

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Laura A. Sordillo, B. B. Das, Yang Pu, Kexian Liang, Giovanni Milione, Peter P. Sordillo, Sam Achilefu, and R. R. Alfano "Time-resolved fluorescence for breast cancer detection using an octreotate-indocyanine green derivative dye conjugate", Proc. SPIE 8577, Optical Biopsy XI, 857708 (19 March 2013); https://doi.org/10.1117/12.2003102

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