Two dimensional photonic crystal biosensors as a platform for label-free sensing of biomolecules

Rashmi Sriram; James E. Baker; Philippe M. Fauchet; Benjamin L. Miller

doi:10.1117/12.2007285

5 March 2013 Two dimensional photonic crystal biosensors as a platform for label-free sensing of biomolecules

Rashmi Sriram, James E. Baker, Philippe M. Fauchet, Benjamin L. Miller

Proceedings Volume 8570, Frontiers in Biological Detection: From Nanosensors to Systems V; 857007 (2013) https://doi.org/10.1117/12.2007285
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Resonant optical microcavites of two-dimensional photonic crystals (2D PhC) are responsive to refractive index changes in the immediate vicinity and thus provide a label-free platform for sensing biological molecules. Because their active sensing volume is ~ 1 μm³, exceptionally sensitive detection of biomolecules is, in principle, achievable from complex biological samples. Previously, we have demonstrated detection of human-IgG protein and virus-like particles by measuring changes in the optical transmission spectrum from the 2D PhC after it has been treated with analyte and dried. However, this drying step restricts practical utility of the platform especially in the case of clinical diagnostics wherein multiple samples need to be tested in short duration. In our progress toward this, we have demonstrated successful integration of microfluidic channels with the 2D PhC device and we further characterized the temperature and bulk refractive index sensitivity of the device.

Citation Download Citation

Rashmi Sriram, James E. Baker, Philippe M. Fauchet, and Benjamin L. Miller "Two dimensional photonic crystal biosensors as a platform for label-free sensing of biomolecules", Proc. SPIE 8570, Frontiers in Biological Detection: From Nanosensors to Systems V, 857007 (5 March 2013); https://doi.org/10.1117/12.2007285

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available