Light dosimetry and dose verification for pleural PDT

Andreea Dimofte; Anna V. Sharikova; Julia L. Meo; Charles B. Simone II; Joseph S. Friedberg; Timothy C. Zhu

doi:10.1117/12.2004941

13 March 2013 Light dosimetry and dose verification for pleural PDT

Andreea Dimofte, Anna V. Sharikova, Julia L. Meo, Charles B. Simone II, Joseph S. Friedberg, Timothy C. Zhu

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85680V (2013) https://doi.org/10.1117/12.2004941
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In-vivo light dosimetry for patients undergoing photodynamic therapy (PDT) is critical for predicting PDT outcome. Patients in this study are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. They are administered 4mg per kg body weight HPPH 48 hours before the surgery and receive light therapy with a fluence of 15-45 J/cm² at 661 and 665nm. Fluence rate (mW/cm²) and cumulative fluence (J/cm²) are monitored at 7 sites during the light treatment delivery using isotropic detectors. Light fluence (rate) delivered to patients is examined as a function of treatment time, volume and surface area. In a previous study, a correlation between the treatment time and the treatment volume and surface area was established. However, we did not include the direct light and the effect of the shape of the pleural surface on the scattered light. A real-time infrared (IR) navigation system was used to separate the contribution from the direct light. An improved expression that accurately calculates the total fluence at the cavity wall as a function of light source location, cavity geometry and optical properties is determined based on theoretical and phantom studies. The theoretical study includes an expression for light fluence rate in an elliptical geometry instead of the spheroid geometry used previously. The calculated light fluence is compared to the measured fluence in patients of different cavity geometries and optical properties. The result can be used as a clinical guideline for future pleural PDT treatment.

Citation Download Citation

Andreea Dimofte, Anna V. Sharikova, Julia L. Meo, Charles B. Simone II, Joseph S. Friedberg, and Timothy C. Zhu "Light dosimetry and dose verification for pleural PDT", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680V (13 March 2013); https://doi.org/10.1117/12.2004941

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KEYWORDS

Sensors

Photodynamic therapy

Calibration

Lung

Navigation systems

Computed tomography

Optical properties

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