Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results

M. T. Huggett; M. Jermyn; A. Gillams; S. Mosse; E. Kent; S. G. Bown M.D.; T. Hasan; B. W. Pogue; S. P. Pereira

doi:10.1117/12.2013648

13 March 2013 Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results

M. T. Huggett, M. Jermyn, A. Gillams, S. Mosse, E. Kent, S. G. Bown M.D., T. Hasan, B. W. Pogue, S. P. Pereira

Proceedings Volume 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII; 85680J (2013) https://doi.org/10.1117/12.2013648
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We undertook a phase I dose-escalation study of verteporfin photodynamic therapy (PDT) in 15 patients with locally advanced pancreatic cancer. Needle placement and laser delivery were technically successful in all patients. Thirteen patients were treated with a single laser fibre. Three treatments were carried out each at 5, 10 and 20 J/cm²; and 5 treatments (4 patients) at 40 J/cm². A further 2 patients were treated with 2 or 3 laser fibres at 40 J/cm². Tumour necrosis was measured on CT (computed tomography) by two radiologists 5 days after treatment. There was a clear dosedependent increase in necrosis with a median area of 20 x 16 mm (range 18 x 16 to 35 x 30 mm) at 40 J/cm². In the 2 patients treated with multiple fibres, necrosis was 40 x 36 mm and 30 x 28 mm, respectively. There were no early complications in patients treated with a single fibre. Both patients treated with multiple fibres had evidence on CT of inflammatory change occurring anterior to the pancreas but without clinical deterioration. These results suggest that single fibre verteporfin PDT is safe in a clinical setting up to 40J/cm² and produces a dose-dependent area of pancreatic necrosis.

Citation Download Citation

M. T. Huggett, M. Jermyn, A. Gillams, S. Mosse, E. Kent, S. G. Bown M.D., T. Hasan, B. W. Pogue, and S. P. Pereira "Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680J (13 March 2013); https://doi.org/10.1117/12.2013648

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available