Compact divided-pupil line-scanning confocal microscope for investigation of human tissues

Christopher Glazowski; Gary Peterson; Milind Rajadhyaksha

doi:10.1117/12.2012630

8 March 2013 Compact divided-pupil line-scanning confocal microscope for investigation of human tissues

Christopher Glazowski, Gary Peterson, Milind Rajadhyaksha

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 856523 (2013) https://doi.org/10.1117/12.2012630
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Divided-pupil line-scanning confocal microscopy (DPLSCM) can provide a simple and low-cost approach for imaging of human tissues with pathology-like nuclear and cellular detail. Using results from a multidimensional numerical model of DPLSCM, we found optimal pupil configurations for improved axial sectioning, as well as control of speckle noise in the case of reflectance imaging. The modeling results guided the design and construction of a simple (10 component) microscope, packaged within the footprint of an iPhone, and capable of cellular resolution. We present the optical design with experimental video-images of in-vivo human tissues.

Citation Download Citation

Christopher Glazowski, Gary Peterson, and Milind Rajadhyaksha "Compact divided-pupil line-scanning confocal microscope for investigation of human tissues", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856523 (8 March 2013); https://doi.org/10.1117/12.2012630

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