Prenatal imaging of distal limb abnormalities using OCT in mice

Irina V. Larina; Saba H. Syed; Mary E. Dickinson; Paul Overbeek; Kirill V. Larin

doi:10.1117/12.909266

30 January 2012 Prenatal imaging of distal limb abnormalities using OCT in mice

Irina V. Larina, Saba H. Syed, Mary E. Dickinson, Paul Overbeek, Kirill V. Larin

Proceedings Volume 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI; 82130B (2012) https://doi.org/10.1117/12.909266
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Congenital abnormalities of the limbs are common birth defects. These include missing or extra fingers or toes, abnormal limb length, and abnormalities in patterning of bones, cartilage or muscles. Optical Coherence Tomography (OCT) is a 3-D imaging modality, which can produce high-resolution (~8 μm) images of developing embryos with an imaging depth of a few millimeters. Here we demonstrate the capability of OCT to perform 3D imaging of limb development in normal embryos and a mouse model with congenital abnormalities. Our results suggest that OCT is a promising tool to analyze embryonic limb development in mammalian models of congenital defects.

Citation Download Citation

Irina V. Larina, Saba H. Syed, Mary E. Dickinson, Paul Overbeek, and Kirill V. Larin "Prenatal imaging of distal limb abnormalities using OCT in mice", Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82130B (30 January 2012); https://doi.org/10.1117/12.909266

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