The in-vivo monitoring method for traumatic brain injury of mouse based on near-infrared light intensity

Weitao Li; Xuena Wang; Zhiyu Qian; Jieru Xie; Xing Liu

doi:10.1117/12.903859

9 February 2012 The in-vivo monitoring method for traumatic brain injury of mouse based on near-infrared light intensity

Weitao Li, Xuena Wang, Zhiyu Qian, Jieru Xie, Xing Liu

Author Affiliations +

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82071N (2012) https://doi.org/10.1117/12.903859
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

A system based on near-infrared light intensity was used to monitor mouse model of traumatic brain injury (TBI) noninvasively. The measurement system was controlled by microcontroller. Light from a 760/850nm dual-wavelength light emitting diode was coupled to a 0.6-mm-diameter optical fiber. The collection fibers were coupled to optoelectronic detectors, which were placed in the different distance from the source fiber. The system consisted of a constant current bias, a circuit lock-in amplifier (including band pass filter, lock-in amplifier, and low pass filter), a PCI 6240 data acquisition card and a multi-core-processor computer. The modified Lambert Beer law was used to calculate the concentration of _ΔHbO₂ and _ΔHb. The sensitivity matrix was defined to evaluate the region of effective detection of optical probe. Five groups of TBI mouse models were built by Feeney's free-falling method. The data measured by system show after TBI the concentration of _ΔHbO₂ decreased and that of _ΔHb increased. It can be concluded that the system can be used to monitor the changes of TBI of mouse non-invasively.

Citation Download Citation

Weitao Li, Xuena Wang, Zhiyu Qian, Jieru Xie, and Xing Liu "The in-vivo monitoring method for traumatic brain injury of mouse based on near-infrared light intensity", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82071N (9 February 2012); https://doi.org/10.1117/12.903859

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available