Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system

James A. Guggenheim; Hamid Dehghani; Hector Basevi; Iain B. Styles; Jon Frampton

doi:10.1117/12.889863

14 June 2011 Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system

James A. Guggenheim, Hamid Dehghani, Hector Basevi, Iain B. Styles, Jon Frampton

Proceedings Volume 8088, Diffuse Optical Imaging III; 80881K (2011) https://doi.org/10.1117/12.889863
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Steps are presented towards the development of a new bioluminescence tomography (BLT) imaging system for in vivo small animal studies. A 2-mirror-based multi-view data collection scheme is investigated in conjunction with multi-spectral imaging, leading to the production of 3D volumetric maps of molecular source distributions in simulation and in physical phantom studies by way of a finite element model (FEM) based reconstruction method. A proof of concept is subsequently demonstrated showing a full work flow from data acquisition to 3D reconstruction. Results suggest that the multi-view mirror-based approach represents a strong improvement over standard single-view methods, with improvements of up to 58% in source localisation accuracy being observed for deep sources.

Citation Download Citation

James A. Guggenheim, Hamid Dehghani, Hector Basevi, Iain B. Styles, and Jon Frampton "Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system", Proc. SPIE 8088, Diffuse Optical Imaging III, 80881K (14 June 2011); https://doi.org/10.1117/12.889863

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