Optical spectroscopy for quantitative sensing in human pancreatic tissues

Robert H. Wilson; Malavika Chandra; William Lloyd; Leng-Chun Chen; James Scheiman; Diane Simeone; Barbara McKenna; Mary-Ann Mycek

doi:10.1117/12.889724

10 June 2011 Optical spectroscopy for quantitative sensing in human pancreatic tissues

Robert H. Wilson, Malavika Chandra, William Lloyd, Leng-Chun Chen, James Scheiman, Diane Simeone, Barbara McKenna, Mary-Ann Mycek

Author Affiliations +

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 808713 (2011) https://doi.org/10.1117/12.889724
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Pancreatic adenocarcinoma has a five-year survival rate of only 6%, largely because current diagnostic methods cannot reliably detect the disease in its early stages. Reflectance and fluorescence spectroscopies have the potential to provide quantitative, minimally-invasive means of distinguishing pancreatic adenocarcinoma from normal pancreatic tissue and chronic pancreatitis. The first collection of wavelength-resolved reflectance and fluorescence spectra and time-resolved fluorescence decay curves from human pancreatic tissues was acquired with clinically-compatible instrumentation. Mathematical models of reflectance and fluorescence extracted parameters related to tissue morphology and biochemistry that were statistically significant for distinguishing between pancreatic tissue types. These results suggest that optical spectroscopy has the potential to detect pancreatic disease in a clinical setting.

Citation Download Citation

Robert H. Wilson, Malavika Chandra, William Lloyd, Leng-Chun Chen, James Scheiman, Diane Simeone, Barbara McKenna, and Mary-Ann Mycek "Optical spectroscopy for quantitative sensing in human pancreatic tissues", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808713 (10 June 2011); https://doi.org/10.1117/12.889724

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