Toward comprehensive detection of sight threatening retinal disease using a multiscale AM-FM methodology

C. Agurto; S. Barriga; V. Murray; S. Murillo; G. Zamora; W. Bauman; M. Pattichis; P. Soliz

doi:10.1117/12.877498

4 March 2011 Toward comprehensive detection of sight threatening retinal disease using a multiscale AM-FM methodology

C. Agurto, S. Barriga, V. Murray, S. Murillo, G. Zamora, W. Bauman, M. Pattichis, P. Soliz

Proceedings Volume 7963, Medical Imaging 2011: Computer-Aided Diagnosis; 796316 (2011) https://doi.org/10.1117/12.877498
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

In the United States and most of the western world, the leading causes of vision impairment and blindness are age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma. In the last decade, research in automatic detection of retinal lesions associated with eye diseases has produced several automatic systems for detection and screening of AMD, DR, and glaucoma. However. advanced, sight-threatening stages of DR and AMD can present with lesions not commonly addressed by current approaches to automatic screening. In this paper we present an automatic eye screening system based on multiscale Amplitude Modulation-Frequency Modulation (AM-FM) decompositions that addresses not only the early stages, but also advanced stages of retinal and optic nerve disease. Ten different experiments were performed in which abnormal features such as neovascularization, drusen, exudates, pigmentation abnormalities, geographic atrophy (GA), and glaucoma were classified. The algorithm achieved an accuracy detection range of [0.77 to 0.98] area under the ROC curve for a set of 810 images. When set to a specificity value of 0.60, the sensitivity of the algorithm to the detection of abnormal features ranged between 0.88 and 1.00. Our system demonstrates that, given an appropriate training set, it is possible to use a unique algorithm to detect a broad range of eye diseases.

Citation Download Citation

C. Agurto, S. Barriga, V. Murray, S. Murillo, G. Zamora, W. Bauman, M. Pattichis, and P. Soliz "Toward comprehensive detection of sight threatening retinal disease using a multiscale AM-FM methodology", Proc. SPIE 7963, Medical Imaging 2011: Computer-Aided Diagnosis, 796316 (4 March 2011); https://doi.org/10.1117/12.877498

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