In vivo interstitial glucose characterization and monitoring in the skin by ATR-FTIR spectroscopy

Natalja Skrebova Eikje M.D.

doi:10.1117/12.874735

10 February 2011 In vivo interstitial glucose characterization and monitoring in the skin by ATR-FTIR spectroscopy

Natalja Skrebova Eikje M.D.

Proceedings Volume 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III; 79060F (2011) https://doi.org/10.1117/12.874735
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Successful development of real-time non-invasive glucose monitoring would represent a major advancement not only in the treatment and management of patients with diabetes mellitus and carbohydrate metabolism disorders, but also for understanding in those biochemical, metabolic and (patho-)physiological processes of glucose at the molecular level in vivo. Here, ATR-FTIR spectroscopy technique has been challenged not only for in vivo measurement of interstitial glucose levels, but also for their non-invasive molecular qualitative and quantitative comparative characterization in the skin tissue. The results, based on calculated mean values of determined 5 glucose-specific peaks in the glucose-related 1000-1160 cm-1 region, showed intra- and inter-subject differences in interstitial glucose activity levels with their changes at different times and doses of OGTT, while raising questions about the relationships between interstitial and blood glucose levels. In conclusion, the introduction of ATR-FTIR spectroscopy technique has opened up an access to the interstitial fluid space in the skin tissue for interstitial glucose characterization and monitoring in vivo. Though interstitial versus blood glucose monitoring has different characteristics, it can be argued that accurate and precise measurements of interstitial glucose levels may be more important clinically.

Citation Download Citation

Natalja Skrebova Eikje M.D. "In vivo interstitial glucose characterization and monitoring in the skin by ATR-FTIR spectroscopy", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060F (10 February 2011); https://doi.org/10.1117/12.874735

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KEYWORDS

Glucose

Skin

Spectroscopy

In vivo imaging

Tissue optics

Blood

FT-IR spectroscopy

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