Modelling and characterization of photothermal effects assisted with gold nanorods in ex vivo samples and in a murine model

Horacio Lamela Rivera; Félix Rodríguez Jara; Vincent Cunningham

doi:10.1117/12.875706

23 February 2011 Modelling and characterization of photothermal effects assisted with gold nanorods in ex vivo samples and in a murine model

Horacio Lamela Rivera, Félix Rodríguez Jara, Vincent Cunningham

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Proceedings Volume 7901, Energy-based Treatment of Tissue and Assessment VI; 79010D (2011) https://doi.org/10.1117/12.875706
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We discuss in this article the implementation of a laser-tissue interaction and bioheat-transfer 2-D finite-element model for Photothermal Therapy assisted with Gold Nanorods. We have selected Gold Nanorods as absorbing nanostructures in order to improve the efficiency of using compact diode lasers because of their high opto-thermal conversion efficiency at 808 and 850 nm. The goal is to model the distribution of the optical energy among the tissue including the skin absorption effects and the tissue thermal response, with and without the presence of Gold Nanorods. The heat generation due to the optical energy absorption and the thermal propagation will be computationally modeled and optimized. The model has been evaluated and compared with experimental ex-vivo data in fresh chicken muscle samples and in-vivo BALB/c mice animal model.

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Horacio Lamela Rivera, Félix Rodríguez Jara, and Vincent Cunningham "Modelling and characterization of photothermal effects assisted with gold nanorods in ex vivo samples and in a murine model", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010D (23 February 2011); https://doi.org/10.1117/12.875706

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KEYWORDS

Tissue optics

Nanorods

Gold

Tissues

Absorption

Finite element methods

Nanoparticles

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