Optical droplet vaporization of micron-sized perfluorocarbon droplets and their photoacoustic detection

Eric Strohm; Min Rui; Ivan Gorelikov; Naomi Matsuura; Michael Kolios

doi:10.1117/12.875401

22 February 2011 Optical droplet vaporization of micron-sized perfluorocarbon droplets and their photoacoustic detection

Eric Strohm, Min Rui, Ivan Gorelikov, Naomi Matsuura, Michael Kolios

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78993H (2011) https://doi.org/10.1117/12.875401
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

An acoustic and photoacoustic characterization of micron-sized perfluorocarbon (PFC) droplets is presented. PFC droplets are currently being investigated as acoustic and photoacoustic contrast agents and as cancer therapy agents. Pulse echo measurements at 375 MHz were used to determine the diameter, ranging from 3.2 to 6.5 μm, and the sound velocity, ranging from 311 to 406 m/s of nine droplets. An average sound velocity of 379 ± 18 m/s was calculated for droplets larger than the ultrasound beam width of 4.0 μm. Optical droplet vaporization, where vaporization of a single droplet occurred upon laser irradiation of sufficient intensity, was verified using pulse echo acoustic methods. The ultrasonic backscatter amplitude, acoustic impedance and attenuation increased after vaporization, consistent with a phase change from a liquid to gas core. Photoacoustic measurements were used to compare the spectra of three droplets ranging in diameter from 3.0 to 6.2 μm to a theoretical model. Good agreement in the spectral features was observed over the bandwidth of the 375 MHz transducer.

Citation Download Citation

Eric Strohm, Min Rui, Ivan Gorelikov, Naomi Matsuura, and Michael Kolios "Optical droplet vaporization of micron-sized perfluorocarbon droplets and their photoacoustic detection", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993H (22 February 2011); https://doi.org/10.1117/12.875401

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