Ultrasound-induced cellular uptake of plasmonic gold nanorods

Alexander Hannah; Katheryne Wilson; Kimberly Homan; Stanislav Emelianov

doi:10.1117/12.875368

28 February 2011 Ultrasound-induced cellular uptake of plasmonic gold nanorods

Alexander Hannah, Katheryne Wilson, Kimberly Homan, Stanislav Emelianov

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789920 (2011) https://doi.org/10.1117/12.875368
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Delivery of contrast agents and their interaction with cells is emerging as an important tool in cancer imaging and therapy. An alternative to traditional molecular targeting schemes that induce endocytotic uptake of contrast agents in cells is presented here. Specifically, the application of high-intensity, focused ultrasound (HIFU) was used to enhance uptake of gold nanorods in pancreatic cancer cells in vitro. A significant increase was observed in gold nanorod uptake when cells were incubated with nanorods and treated with HIFU. Additionally, inclusion of liquid-filled, perfluorocarbon (PFC) microdroplets in cell samples incubated with nanorods and treated with HIFU exhibited greater uptake of gold over those samples exposed to HIFU without microdroplets. Furthermore, the level of acoustic pressure required to increase nanoparticle uptake did not significantly decrease cell viability. Therefore, improved intracellular delivery of nanoparticle contrast agents is possible using HIFU without compromising cell viability. Since nanoparticle delivery is mechanically induced, this method can apply to a broad range of cancer imaging and therapy applications.

Citation Download Citation

Alexander Hannah, Katheryne Wilson, Kimberly Homan, and Stanislav Emelianov "Ultrasound-induced cellular uptake of plasmonic gold nanorods", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789920 (28 February 2011); https://doi.org/10.1117/12.875368

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