A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

Yi Yang; Nrusingh C. Biswal; Tianheng Wang; Patrick Kumavor; Mozafareddin Karimeddini; Melinda Sanders; Molly Brewer; Quing Zhu

doi:10.1117/12.878860

10 February 2011 A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

Yi Yang, Nrusingh C. Biswal, Tianheng Wang, Patrick Kumavor, Mozafareddin Karimeddini, Melinda Sanders, Molly Brewer, Quing Zhu

Author Affiliations +

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920Y (2011) https://doi.org/10.1117/12.878860
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.

Citation Download Citation

Yi Yang, Nrusingh C. Biswal, Tianheng Wang, Patrick Kumavor, Mozafareddin Karimeddini, Melinda Sanders, Molly Brewer, and Quing Zhu "A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920Y (10 February 2011); https://doi.org/10.1117/12.878860

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