Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Rajan Arora; Georgi I. Petrov; Hao F. Zhang; Vladislav V. Yakovlev

doi:10.1117/12.875442

21 February 2011 Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Rajan Arora, Georgi I. Petrov, Hao F. Zhang, Vladislav V. Yakovlev

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920N (2011) https://doi.org/10.1117/12.875442
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.

Citation Download Citation

Rajan Arora, Georgi I. Petrov, Hao F. Zhang, and Vladislav V. Yakovlev "Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920N (21 February 2011); https://doi.org/10.1117/12.875442

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