MRI-guided fluorescence tomography of PPIX in the breast: a case study

Scott C. Davis; Michael A. Mastanduno; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/12.875775

10 February 2011 MRI-guided fluorescence tomography of PPIX in the breast: a case study

Scott C. Davis, Michael A. Mastanduno, Brian W. Pogue, Keith D. Paulsen

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920M (2011) https://doi.org/10.1117/12.875775
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A case study to demonstrate fluorescence tomography of endogenous protoporphyrin IX (PPIX) in breast cancer is presented. An MRI-coupled fluorescence tomography system with spectrometer detectors was used to acquire excitation and emission data through the breast of a human subject undergoing chemotherapy for breast cancer. Volumetric images of PPIX fluorescence showed elevated levels of fluorescence activity in the fibro-glandular tissue as compared to the adipose tissue. Fluorescence levels in the tumor were higher than in the adipose tissue but lower than the fibro-glandular tissue.

Citation Download Citation

Scott C. Davis, Michael A. Mastanduno, Brian W. Pogue, and Keith D. Paulsen "MRI-guided fluorescence tomography of PPIX in the breast: a case study", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920M (10 February 2011); https://doi.org/10.1117/12.875775

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