DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions in diagnosis of skin cancers by FT-IR microspectroscopy

Natalja Skrebova Eikje

doi:10.1117/12.874692

17 February 2011 DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions in diagnosis of skin cancers by FT-IR microspectroscopy

Natalja Skrebova Eikje

Author Affiliations +

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78830T (2011) https://doi.org/10.1117/12.874692
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Skin tissue infrared (IR) microspectroscopy may work as an optical diagnostic method for common skin cancer detection, progression, and specific characterization of carcinogenesis in skin tumours. Spectral results from BCC, SCC and MM skin samples demonstrated significant levels of the multiplet at about 1055 cm^-1. Its activity level strongly correlated with the activity level of the most prominent peak in DNA/RNA triad in 5 BCC, in 3 SCC and only in 1 MM patient. DNA-RNA and DNA-DNA interactions as I₉₆₅ < I₁₀₅₅ < I_{max level DNA/RNA triad peak} were the most clearly observed in 3 BCC patients with high-leveled peaks of nucleic acids, that were presented as I₉₆₅ < I₁₀₅₅ > I_{max level DNA/RNA triad peak} in 3 SCC patients with the highest activity levels. Although mean values and the intensities of nucleic acids in the patients with MM showed strong correlation between each other, independent on the level of their activity, interactions differed individually. DNA-protein interactions were mostly expressed between intensities of DNA/RNA triad peaks and non-descriptive proteins, that were in agreement between BCC and SCC, but not in MM. Protein-protein interactions were similar among the patients, generally indicating the grade of activity in cells in tissues.

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Natalja Skrebova Eikje "DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions in diagnosis of skin cancers by FT-IR microspectroscopy", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78830T (17 February 2011); https://doi.org/10.1117/12.874692

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