Biconical tapered optical fiber biosensor for measuring refractive index of a-amino acids in aqueous D-glucose and sucrose solution

M. I. Zibaii; H. Latifi; M. Karami; M. Gholami; S. M. Hosseini; M. H. Ghezelayagh

doi:10.1117/12.853969

18 May 2010 Biconical tapered optical fiber biosensor for measuring refractive index of a-amino acids in aqueous D-glucose and sucrose solution

M. I. Zibaii, H. Latifi, M. Karami, M. Gholami, S. M. Hosseini, M. H. Ghezelayagh

Author Affiliations +

Proceedings Volume 7715, Biophotonics: Photonic Solutions for Better Health Care II; 77151Y (2010) https://doi.org/10.1117/12.853969
Event: SPIE Photonics Europe, 2010, Brussels, Belgium

Abstract

A single-mode biconical tapered optical fiber (BTOF) sensor was utilized for sensing the variation of refractive index (RI) with concentration of D-glucose in double distilled deionized water and measuring of RI of amino acids (AAs) in carbohydrate solutions. This method showed a rewarding ability in understanding the basis of biomolecular interactions in biological systems. The BTOF is fabricated by heat pulling method, utilizing a CO₂ laser. The detection limit of the BTOF was 50 ppb for the D-glucose concentration ranging from 0 to 80 ppm, and RI detection limit corresponding to these concentrations in the range at 1.3333 to 1.3404 was 5.4×10^-6 as a refractometer sensor. The response of the BTOF shows that the different kinds of interactions of various groups of AAs such as L-alanine, L-leucine, and L-cystein with D-glucose, sucrose and water molecules depend on functional groups in AAs such as OH, SH;CH₂;NH₃⁺ ,COO^-. These results can be interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.

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M. I. Zibaii, H. Latifi, M. Karami, M. Gholami, S. M. Hosseini, and M. H. Ghezelayagh "Biconical tapered optical fiber biosensor for measuring refractive index of a-amino acids in aqueous D-glucose and sucrose solution", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151Y (18 May 2010); https://doi.org/10.1117/12.853969

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KEYWORDS

Molecules

Molecular interactions

Refractive index

Glucose

Sensors

Tapered optical fibers

Fiber optics sensors

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