Application of ceramic phosphors for near infrared biomedical imaging technologies

Kohei Soga; Kimikazu Tokuzen; Kosuke Tsuji; Tomoyoshi Yamano; Nallusamy Venkatachalam; Hiroshi Hyodo; Hidehiro Kishimoto

doi:10.1117/12.841516

25 February 2010 Application of ceramic phosphors for near infrared biomedical imaging technologies

Kohei Soga, Kimikazu Tokuzen, Kosuke Tsuji, Tomoyoshi Yamano, Nallusamy Venkatachalam, Hiroshi Hyodo, Hidehiro Kishimoto

Author Affiliations +

Proceedings Volume 7598, Optical Components and Materials VII; 759807 (2010) https://doi.org/10.1117/12.841516
Event: SPIE OPTO, 2010, San Francisco, California, United States

Abstract

Near infrared wavelength region between 0.8 and 2 μm is an attractive region for biomedical imaging due to the low loss in biomedical objects in the region. Rare-earth doped ceramic phosphors are known to emit efficient fluorescence in the same wavelength region. The authors have developed micro fluorescence bioimaging system for cellular or tissue imaging and macro one for in vivo imaging. This paper will review the materials synthesis for the near infrared fluorescence probes as well as the system development and demonstrative works. Er-doped or Yb/Er-doped ceramic phosphors were synthesized with required particle size. The phosphors were partly modified with polyethylene glycol to give dispersion and controlled interaction with the biological objects. By using the micro imaging system, nematodes, mouse tissue and M1 cells were observed by detecting 1.5 μm emission from Er doped in the ceramic phosphor. in vivo imaging with the same fluorescence scheme was also performed for the digestive organs of live mouse.

Citation Download Citation

Kohei Soga, Kimikazu Tokuzen, Kosuke Tsuji, Tomoyoshi Yamano, Nallusamy Venkatachalam, Hiroshi Hyodo, and Hidehiro Kishimoto "Application of ceramic phosphors for near infrared biomedical imaging technologies", Proc. SPIE 7598, Optical Components and Materials VII, 759807 (25 February 2010); https://doi.org/10.1117/12.841516

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