Stokes shift spectroscopy for breast cancer diagnosis

Ebenezar Jeyasingh; Aruna Prakashrao; Ganesan Singaravelu

doi:10.1117/12.840196

11 February 2010 Stokes shift spectroscopy for breast cancer diagnosis

Ebenezar Jeyasingh, Aruna Prakashrao, Ganesan Singaravelu

Proceedings Volume 7561, Optical Biopsy VII; 75610B (2010) https://doi.org/10.1117/12.840196
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The objective of this study is to assess the diagnostic potential of stokes shift (SS) spectroscopy (SSS) for normal and different pathological breast tissues such as fibroadenoma and infiltrating ductal carcinoma. The SS spectra is measured by simultaneously scanning both the excitation and emission wavelengths while keeping a fixed wavelength interval Δλ=20 nm between them. Characteristic, highly resolved peaks and significant spectral differences between normal and different pathological breast tissues were observed. The SS spectra of normal and different pathological breast tissues shows the distinct peaks around 300, 350, 450, 500 and 600 nm may be attributed to tryptophan, collagen, NADH, flavin and porphyrin respectively. Using SSS technique one can obtain all the key fluorophores in a single scan and hence they can be targeted as a tumor markers in this study. In order to quantify the altered spectral differences between normal and different pathological breast tissues are verified by different ratio parameters.

Citation Download Citation

Ebenezar Jeyasingh, Aruna Prakashrao, and Ganesan Singaravelu "Stokes shift spectroscopy for breast cancer diagnosis", Proc. SPIE 7561, Optical Biopsy VII, 75610B (11 February 2010); https://doi.org/10.1117/12.840196

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