A fiber-based, non-contact scheme for time-domain diffuse fluorescence tomography: methodology and simulative validation

Feng Gao; Meng Jing; Jiao Li; Farouk Nouizi; Patrick Poulet; Limin Zhang; Huijuan Zhao

doi:10.1117/12.834836

23 February 2010 A fiber-based, non-contact scheme for time-domain diffuse fluorescence tomography: methodology and simulative validation

Feng Gao, Meng Jing, Jiao Li, Farouk Nouizi, Patrick Poulet, Limin Zhang, Huijuan Zhao

Author Affiliations +

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570O (2010) https://doi.org/10.1117/12.834836
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Non-contact scheme is prevalent to diffuse fluorescence tomography (FDT) since it facilitates instrumentation as well as simplifies experimental procedure. Although non-contact FDT generally uses CCD camera as detectors to achieve high throughput of data collection, a fiber-based implementation can make full use of well-established high-sensitive and time-resolved detection techniques. Therefore, a system that combines the fiber-based time-resolved detection and the non-contact geometry of optodes would be significantly attractive, which also means a more complex modeling of photon migration. This paper presents detailed computational aspects of the fiber-based non-contact DFT, including both the forward and inverse models. A pilot validation of the method is performed using simulated data for a two-dimensional case.

Citation Download Citation

Feng Gao, Meng Jing, Jiao Li, Farouk Nouizi, Patrick Poulet, Limin Zhang, and Huijuan Zhao "A fiber-based, non-contact scheme for time-domain diffuse fluorescence tomography: methodology and simulative validation", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570O (23 February 2010); https://doi.org/10.1117/12.834836

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