A laser device for fusion of nasal mucosa

Valmiki Sooklal; Jesse McClure; Luke Hooper; Michael Larson

doi:10.1117/12.843854

2 March 2010 A laser device for fusion of nasal mucosa

Valmiki Sooklal, Jesse McClure, Luke Hooper, Michael Larson

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75482N (2010) https://doi.org/10.1117/12.843854
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A prototype device has been created to fuse septal tissue membranes as an alternative to sutures or staples through the controlled application of laser heating and pressure to induce protein denaturation and subsequent tissue fusion, through renaturation and intertwining, across the interface. Lasers have been used to close wounds in controlled laboratory tests over the last 15 years. Many encouraging results have been obtained; however, no commercial delivery systems are currently available. This is due primarily to two factors: requiring an inordinate amount of experience on the part of the operator, and attempting to achieve general applicability for multiple tissue systems. The present device overcomes these barriers as it is tailored for the particular application of septal laser fusion, namely for the coaptation of mucoperichondrial membranes. The important parameters involved in fusing biological tissues are identified. The development of the device followed from computational modeling based on Monte Carlo simulation of photon transport and on engineering firstprinciples. Experiments were designed and analyzed using orthogonal arrays, employing a subset of the relevant parameters, i.e., laser irradiance, dwell time and spot size, for a range of wavelengths. The in vitro fusion experiments employed 1cm by 1cm sections of equine nasal mucosa having a nominal thickness of 1mm.

Citation Download Citation

Valmiki Sooklal, Jesse McClure, Luke Hooper, and Michael Larson "A laser device for fusion of nasal mucosa", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75482N (2 March 2010); https://doi.org/10.1117/12.843854

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Laser tissue interaction

Tissues

Laser welding

Tissue optics

Monte Carlo methods

Natural surfaces

Laser energy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years