THz spectra of cortisone and the related medicine

Shihua Ma; Min Ge; Guifeng Liu; Xiyu Song; Peng Zhang; Wenfeng Wang

doi:10.1117/12.836106

4 August 2009 THz spectra of cortisone and the related medicine

Shihua Ma, Min Ge, Guifeng Liu, Xiyu Song, Peng Zhang, Wenfeng Wang

Proceedings Volume 7385, International Symposium on Photoelectronic Detection and Imaging 2009: Terahertz and High Energy Radiation Detection Technologies and Applications; 738520 (2009) https://doi.org/10.1117/12.836106
Event: International Symposium on Photoelectronic Detection and Imaging 2009, 2009, Beijing, China

Abstract

THz-TDS are used to study four kinds of drug: cortisone, hydrocortisone, prednisone and prednisolone. The THz spectra of them are obtained and analyzed from 0.2 - 1.6 THz. The experimental results shows the four samples have the different THz spectra. Cortisone has a peak at 1.5 THz and a broad absorption peak at 0.96 THz, while hydrocortisone has a weak absorption peak that lies at 1.27 THz. At the same time the prednisone has the stronger absorption peaks than the others, and its two peaks shows at 1.24 THz and 1.5 THz. Prednisolone has a weak broad peak at 1.43 THz. The results of the theoretical calculation were performed using Gaussian 03 software with Density Functional Theory at the basis set of 6-31+G (d, p). The theoretical vibrational frequencies are compared with the experimental results, and the deviations are discussed. The THz spectra of the medicine show THz technique may be help to distinguish some different chemical bond and functional group.

Citation Download Citation

Shihua Ma, Min Ge, Guifeng Liu, Xiyu Song, Peng Zhang, and Wenfeng Wang "THz spectra of cortisone and the related medicine", Proc. SPIE 7385, International Symposium on Photoelectronic Detection and Imaging 2009: Terahertz and High Energy Radiation Detection Technologies and Applications, 738520 (4 August 2009); https://doi.org/10.1117/12.836106

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