Fluorescence diagnosis in tissue injury

Vitória Helena Maciel; Juliana Ferreira; Vanderlei S. Bagnato

doi:10.1117/12.823019

13 July 2009 Fluorescence diagnosis in tissue injury

Vitória Helena Maciel, Juliana Ferreira, Vanderlei S. Bagnato

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73805B (2009) https://doi.org/10.1117/12.823019
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Background and Objectives: The paper aim was to evaluate the efficacy of the fluorescence spectroscopy in the detection of UV-induced skin change of Wistar rats. Study Design/ Materials and Methods: In a group male Wistar rats, the skin damage was produced by an UV-C lamp, periodically monitored using the laser-induced fluorescence, until complete healing process. After determining a characteristic emission band present in the fluorescence spectra of the induced injuries, the amplitude band monitoring allowed the follow up on the injury and the recovery. Results: We observed the appearance of two new emission bands more evident at the injury spectra when compared to the spectrums from normal non-exposed tissue. Following such spectral bands was possible to observe the establishment and recovery. Conclusions: The fluorescence spectroscopy is a promising technique in distinguishing between normal and UV induced skin change helping the evaluation of changes which are irreversible cancer tissue characteristics.

Citation Download Citation

Vitória Helena Maciel, Juliana Ferreira, and Vanderlei S. Bagnato "Fluorescence diagnosis in tissue injury", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73805B (13 July 2009); https://doi.org/10.1117/12.823019

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