Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography

Yuting Lin; William C. Barber; Jan S. Iwanczyk; Einar Nygard; Nail Malakov; Neal E. Hartsough; Thulasi Gandhi; Werner W. Roeck; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.831719

1 July 2009 Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography

Yuting Lin, William C. Barber, Jan S. Iwanczyk, Einar Nygard, Nail Malakov, Neal E. Hartsough, Thulasi Gandhi, Werner W. Roeck, Orhan Nalcioglu, Gultekin Gulsen

Author Affiliations +

Proceedings Volume 7370, Molecular Imaging II; 73700G (2009) https://doi.org/10.1117/12.831719
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

We demonstrate the feasibility of using a dual-modality fluorescence and x-ray computed tomography (CT) system for quantitative molecular imaging with phantom studies. A CCD based non-contact FT system, which can take measurements from multiple views was built. High-resolution X-Ray CT was used to obtain structural information from the phantom. A 3.6 mm diameter fluorescence inclusion was deeply embedded in the heterogeneous optical background. The results demonstrated that the fluorophore concentration can only be obtained accurately when guided by the a priori information provided by the x-ray CT.

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Yuting Lin, William C. Barber, Jan S. Iwanczyk, Einar Nygard, Nail Malakov, Neal E. Hartsough, Thulasi Gandhi, Werner W. Roeck, Orhan Nalcioglu, and Gultekin Gulsen "Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography", Proc. SPIE 7370, Molecular Imaging II, 73700G (1 July 2009); https://doi.org/10.1117/12.831719

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