Nondestructive quantification of permeability of hyperosmotic agent in normal and tumor tissues

Honglian Xiong; Zhouyi Guo; Changchun Zeng; Like Wang; Yonghong He; Songhao Liu

doi:10.1117/12.821348

6 March 2009 Nondestructive quantification of permeability of hyperosmotic agent in normal and tumor tissues

Honglian Xiong, Zhouyi Guo, Changchun Zeng, Like Wang, Yonghong He, Songhao Liu

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 728025 (2009) https://doi.org/10.1117/12.821348
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

Noninvasive tumor imaging could lead to the early detection and timely treatment of cancer. Previous investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool distinguishing normal tissues from tumor tissues based on structural imaging because of the high resolution. In the study, the capability of OCT for functional imaging of normal and tumor tissues based on time and depth resolved quantification of the permeability of biomolecules through these tissues is investigated. An OCT system at 830 nm central wavelength was used in this study. Diffusion of 20% aqueous solution of glucose was monitored and quantified in normal stomach tissues and tumor tissues using OCT. The orthotopic graft model of gastric cancer in nude mice was used. Permeability coefficients were calculated as a function of time and tissue depth. The permeability coefficient was (9.44±0.42) ×10^-6 cm/s in normal stomach tissues and (5.32±0.17)×10^-5 cm/s in tumor tissues. The tumor tissues had a higher permeability coefficient compared to normal tissues. From the experimental results, it is found that the accurate and sensitive assessment of the permeability coefficients of normal and tumor tissues offer an effective OCT image method for clinical diagnosis and detection of tumor tissues.

Citation Download Citation

Honglian Xiong, Zhouyi Guo, Changchun Zeng, Like Wang, Yonghong He, and Songhao Liu "Nondestructive quantification of permeability of hyperosmotic agent in normal and tumor tissues", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 728025 (6 March 2009); https://doi.org/10.1117/12.821348

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissues

Optical coherence tomography

Tumors

Glucose

Stomach

Diffusion

Nondestructive evaluation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years