Brain tumor resection guided by fluorescence imaging and MRI image guidance

Pablo Valdes; Brent T. Harris; Frederic Leblond; Kathryn M. Fontaine; Songbai Ji; Brian W. Pogue; Alex Hartov; David W. Roberts; Keith D. Paulsen

doi:10.1117/12.813868

13 March 2009 Brain tumor resection guided by fluorescence imaging and MRI image guidance

Pablo Valdes, Brent T. Harris, Frederic Leblond, Kathryn M. Fontaine, Songbai Ji, Brian W. Pogue, Alex Hartov, David W. Roberts, Keith D. Paulsen

Author Affiliations +

Proceedings Volume 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling; 726103 (2009) https://doi.org/10.1117/12.813868
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Recent evidence suggests a correlation between extent of tumor resection and patient prognosis, making maximal tumor resection a clinical ideal for neurosurgeons. Our group is currently undertaking a clinical study using fluorescence-based detection of tumor coupled with a standard 3-D image guidance system to study the effectiveness of fluorescence-based detection in the neurosurgical operating room. For fluorescence-based detection, we used 5-aminolevulinic acid to induce accumulation of protoporphyrin IX in malignant tissues. In this paper, we chose one prototypical, highly fluorescent case of glioblastoma multiforme, a high-grade glioma, to highlight some of the key findings and methodology used in our study of fluorescence-based detection and resection of brain tumors.

Citation Download Citation

Pablo Valdes, Brent T. Harris, Frederic Leblond, Kathryn M. Fontaine, Songbai Ji, Brian W. Pogue, Alex Hartov, David W. Roberts, and Keith D. Paulsen "Brain tumor resection guided by fluorescence imaging and MRI image guidance", Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 726103 (13 March 2009); https://doi.org/10.1117/12.813868

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