Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography

Yi Fan; Jing Wang; Hongbing Lu; Zhengrong Liang

doi:10.1117/12.811670

13 March 2009 Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography

Yi Fan, Jing Wang, Hongbing Lu, Zhengrong Liang

Author Affiliations +

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 725856 (2009) https://doi.org/10.1117/12.811670
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Currently available spiral/helical computed tomography (HCT) technologies have demonstrated the potential for CTbased virtual colonoscopy or CT-colonography (CTC). However, a major limitation for this clinical application is associated with the risk of high radiation exposure, especially for its use for screening purpose at a large population. In this work, we presented an improved Karhunen-Loeve (KL) domain penalized weighted least-squares (PWLS) strategy which considers the data correlation among the nearby angular views and nearby axial slices simultaneously so that a fully three-dimensional (3D) restoration problem can be reduced to a 1D operation and therefore an analytical calculation is feasible for highest computing efficiency. The KL-PWLS strategy was implemented and tested on computer simulated sinograms which mimic low-dose CT scans at different noise levels characterized by 50, 40, 30, 20 and 10 mAs respectively. The reconstructed images by the presented strategy demonstrated the potential of ultra low-dose CT at as low as 10 mAs for VC application. Further evaluation by receiver operating characteristic study is needed and is under progress.

Citation Download Citation

Yi Fan, Jing Wang, Hongbing Lu, and Zhengrong Liang "Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725856 (13 March 2009); https://doi.org/10.1117/12.811670

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE