Femtosecond laser scalpel technology for proteomic mass spectrometry

C. L. Kalcic; T. C. Gunaratne; G. E. Reid; A. D. Jones; M. Dantus

doi:10.1117/12.808934

24 February 2009 Femtosecond laser scalpel technology for proteomic mass spectrometry

C. L. Kalcic, T. C. Gunaratne, G. E. Reid, A. D. Jones, M. Dantus

Proceedings Volume 7203, Commercial and Biomedical Applications of Ultrafast Lasers IX; 72030C (2009) https://doi.org/10.1117/12.808934
Event: SPIE LASE: Lasers and Applications in Science and Engineering, 2009, San Jose, California, United States

Abstract

Tandem mass spectrometry is a widely used tool for molecular structure determination of biomolecules. Advances in proteome analysis depend on the development of improved methods for ion activation that yield greater sequence information, with selective control over the fragmentation chemistry. A novel activation method, femtosecond laser-induced ionization/dissociation, is described here, and compared to collision induced dissociation through the analysis of three peptides.

Citation Download Citation

C. L. Kalcic, T. C. Gunaratne, G. E. Reid, A. D. Jones, and M. Dantus "Femtosecond laser scalpel technology for proteomic mass spectrometry", Proc. SPIE 7203, Commercial and Biomedical Applications of Ultrafast Lasers IX, 72030C (24 February 2009); https://doi.org/10.1117/12.808934

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