Efficacy of photothermal ablation using intravenously delivered NIR-absorbing nanorods in colon cancer

Glenn P. Goodrich; J. Donald Payne; Kelly Sharp; LiLi Bao; Kristina L. Sang

doi:10.1117/12.807883

12 February 2009 Efficacy of photothermal ablation using intravenously delivered NIR-absorbing nanorods in colon cancer

Glenn P. Goodrich, J. Donald Payne, Kelly Sharp, LiLi Bao, Kristina L. Sang

Proceedings Volume 7181, Energy-based Treatment of Tissue and Assessment V; 71810Q (2009) https://doi.org/10.1117/12.807883
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The use of near-infrared absorbing nanoparticles recently has been proposed for the minimally invasive photothermal ablation of solid tumors, and this approach currently is being investigated in the clinic. One class of nanoparticles, gold nanorods, has been investigated for the ablation of various cancer types using both direct injection and systemic delivery. Here we investigate the photothermal ablation of colon cancer in an animal model using intravenously delivered gold nanorods. Nanorods with an aspect ratio of ~3.2 and an extinction peak of 774 nm were PEGylated, suspended in an isotonic solution, and infused into the tail vein of BALB/c mice bearing subcutaneous CT26.wt murine colon cancer tumors. After 24 hrs, an isotropic laser fiber was inserted through a small incision in the skin to a point proximate to and beneath the tumor. The area was illuminated with 3.5 W average power for 3 minutes. Control groups consisted of laser-only, nanorod-only and untreated tumored animals. The survival of the animals receiving nanorod-based photothermal ablation was statistically longer than the control groups with >44% complete response. This work demonstrates the promise of systemically delivering nanoparticles to tumors for thermal ablation

Citation Download Citation

Glenn P. Goodrich, J. Donald Payne, Kelly Sharp, LiLi Bao, and Kristina L. Sang "Efficacy of photothermal ablation using intravenously delivered NIR-absorbing nanorods in colon cancer", Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810Q (12 February 2009); https://doi.org/10.1117/12.807883

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