Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall; Mark J. Hsu; Sadik Esener; Robert F. Mattrey

doi:10.1117/12.808603

12 February 2009 Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles

David J. Hall, Mark J. Hsu, Sadik Esener, Robert F. Mattrey

Proceedings Volume 7177, Photons Plus Ultrasound: Imaging and Sensing 2009; 71771L (2009) https://doi.org/10.1117/12.808603
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

Citation Download Citation

David J. Hall, Mark J. Hsu, Sadik Esener, and Robert F. Mattrey "Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71771L (12 February 2009); https://doi.org/10.1117/12.808603

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