Multispectral and phase-contrast diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study

Xiaoping Liang; Qizhi Zhang; Stephen Staal; Stephen Grobmyer; Huabei Jiang

doi:10.1117/12.809565

12 February 2009 Multispectral and phase-contrast diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study

Xiaoping Liang, Qizhi Zhang, Stephen Staal, Stephen Grobmyer, Huabei Jiang

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71742C (2009) https://doi.org/10.1117/12.809565
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Multispectral and phase-contrast diffuse optical tomography are used to track treatment progress in a patient with locally advanced invasive carcinoma of the breast cancer during neoadjuvant chemotherapy. Two types of chemotherapy treatment including four cycles of Adriamycin/Cytoxin (AC cycles) and twelve cycles of Taxol/Herceptin (TH cycles) were applied to patient. A total of eight optical exams were performed before and within the chemotherapy. Images of tissue refractive index, and absorption and scattering coefficients, as well as oxy-hemoglobin and deoxy-hemoglobin concentrations along with scattering particle volume fraction and mean diameter of cellular components were all obtained. The tumor was identified through absorption and scattering images. Tumor shrinkage was observed during the course of chemotherapy from all the optical images. Our results show that oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin in tumor decreased after chemotherapy compared to that of before chemotherapy. Significant changes in tumor refractive index along with tumor cellular morphology during the entire chemotherapy are also observed.

Citation Download Citation

Xiaoping Liang, Qizhi Zhang, Stephen Staal, Stephen Grobmyer, and Huabei Jiang "Multispectral and phase-contrast diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71742C (12 February 2009); https://doi.org/10.1117/12.809565

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KEYWORDS

Tumors

Scattering

Absorption

Breast

Tissues

Breast cancer

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