Development and validation of a system based on spectral-photometry for measuring fluid dynamics of multi-infusion conditions in intensive care units

Annemoon Timmerman; Brechtje Riphagen; John Klaessens; Rudolf Verdaasdonk

doi:10.1117/12.809534

23 February 2009 Development and validation of a system based on spectral-photometry for measuring fluid dynamics of multi-infusion conditions in intensive care units

Annemoon Timmerman, Brechtje Riphagen, John Klaessens, Rudolf Verdaasdonk

Author Affiliations +

Proceedings Volume 7170, Design and Quality for Biomedical Technologies II; 71700F (2009) https://doi.org/10.1117/12.809534
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Multi-infusion setups for medication administration in Intensive Care Units seem uncontrolled due to flow and pressure differences between syringe pumps. To investigate the dynamics and interaction of multi-infusion, a dedicated set-up was developed to measure the concentrations of fluids dynamically in multiple lines using absorption spectral-photometry. For feasibility testing and calibration, various dyes and concentrations were investigated to find the optimal settings. The developed method was validated and showed satisfactory results for determining mixtures of up to three different dyes in different ratios, with average recoveries of 105.0% (±11.01) for two dyes and 99.6% (±6.26) for three dyes. The method was applied in initial simulation experiments for measuring effects of manipulations in a multi-infusion set-up simulating a clinical situation. Results showed evidence for mutual influencing of separate infusion lines. The method developed for measuring the fluid dynamics of multi-infusion will contribute to a better insight and controlled administration of medications.

Citation Download Citation

Annemoon Timmerman, Brechtje Riphagen, John Klaessens, and Rudolf Verdaasdonk "Development and validation of a system based on spectral-photometry for measuring fluid dynamics of multi-infusion conditions in intensive care units", Proc. SPIE 7170, Design and Quality for Biomedical Technologies II, 71700F (23 February 2009); https://doi.org/10.1117/12.809534

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