Visible and near infrared autofluorescence and hyperspectral imaging spectroscopy for the investigation of colorectal lesions and detection of exogenous fluorophores

Kevin R. Koh; Tobias C. Wood; Robert D Goldin; Guang-Zhong Yang; Daniel S. Elson

doi:10.1117/12.809313

23 February 2009 Visible and near infrared autofluorescence and hyperspectral imaging spectroscopy for the investigation of colorectal lesions and detection of exogenous fluorophores

Kevin R. Koh, Tobias C. Wood, Robert D Goldin, Guang-Zhong Yang, Daniel S. Elson

Author Affiliations +

Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 71691E (2009) https://doi.org/10.1117/12.809313
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Colonoscopy is the most widely prescribed colonic imaging method for the clinical surveillance of colorectal cancer for the detection of adenomatous polyps. However, some adenomas appear diminutive and flat, making them difficult to discriminate from non-neoplastic tissue even for the most experienced colonoscopists. We report here an optical system for performing excitation resolved visible and near-infrared autofluorescence imaging and hyperspectral imaging for the accurate distinction between neoplastic and non-neoplastic tissue. This is demonstrated on ex vivo colorectal tissues using our multimodal imaging system, which has potential applications for the in vivo endoscopic imaging and diagnosis of colorectal cancer tissue.

Citation Download Citation

Kevin R. Koh, Tobias C. Wood, Robert D Goldin, Guang-Zhong Yang, and Daniel S. Elson "Visible and near infrared autofluorescence and hyperspectral imaging spectroscopy for the investigation of colorectal lesions and detection of exogenous fluorophores", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691E (23 February 2009); https://doi.org/10.1117/12.809313

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